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Assay Detail

CHEMBL1776452

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
Maj J, Morzycki JW, Rárová L, Oklest'ková J, Strnad M, Wojtkielewicz A.
J Med Chem (2011) 54 : 3298 -3305
PubMed 21438635 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.01 8.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL375269 1 8.47
CHEMBL1775021 1 7.52
CHEMBL1775023 1 7.38
CHEMBL1775022 1 7.33
CHEMBL1775027 1 7.21
CHEMBL1775024 1 7.17
CHEMBL1775028 1 6.99
CHEMBL1775020 1 6.77
CHEMBL1775019 1 6.70
CHEMBL1775030 1 6.47
CHEMBL1775025 1 6.36
CHEMBL1775026 1 5.71
CHEMBL1775018 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL375269 IC50 = 3.4 nM 8.47
CHEMBL1775021 IC50 = 30.0 nM 7.52
CHEMBL1775023 IC50 = 42.0 nM 7.38
CHEMBL1775022 IC50 = 47.0 nM 7.33
CHEMBL1775027 IC50 = 61.0 nM 7.21
CHEMBL1775024 IC50 = 67.0 nM 7.17
CHEMBL1775028 IC50 = 103.0 nM 6.99
CHEMBL1775020 IC50 = 170.0 nM 6.77
CHEMBL1775019 IC50 = 200.0 nM 6.70
CHEMBL1775030 IC50 = 340.0 nM 6.47
CHEMBL1775025 IC50 = 435.0 nM 6.36
CHEMBL1775026 IC50 = 1940.0 nM 5.71
CHEMBL1775018 IC50 > 50000.0 nM -