Assay Detail
Functional
CHEMBL1776453
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Cytotoxicity against human HOS cells assessed as viable cells after 72 hrs by calcein AM assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HOS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.44 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1775023 | — | — | 1 | 5.72 |
| CHEMBL1775028 | — | — | 1 | 5.71 |
| CHEMBL1775024 | — | — | 1 | 5.57 |
| CHEMBL1775022 | — | — | 1 | 5.55 |
| CHEMBL1775030 | — | — | 1 | 5.27 |
| CHEMBL1775027 | — | — | 1 | 5.19 |
| CHEMBL375269 | — | — | 1 | 5.09 |
| CHEMBL1775018 | — | — | 1 | - |
| CHEMBL1775025 | — | — | 1 | - |
| CHEMBL1775026 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1775023 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1775028 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL1775024 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1775022 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1775030 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1775027 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL375269 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1775018 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1775025 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1775026 | — | IC50 | > | 50000.0 | nM | - |