Assay Detail
Functional
CHEMBL1776593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells over expressing RSK2 after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.10 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | — | 1 | 5.75 |
| CHEMBL1775071 | — | — | 1 | 5.01 |
| CHEMBL1775067 | — | — | 1 | 4.83 |
| CHEMBL529177 | — | — | 1 | 4.79 |
| CHEMBL1775068 | — | — | 1 | - |
| CHEMBL1775069 | — | — | 1 | - |
| CHEMBL1775070 | — | — | 1 | - |
| CHEMBL1775072 | — | — | 1 | - |
| CHEMBL1775073 | — | — | 1 | - |
| CHEMBL1775074 | — | — | 1 | - |
| CHEMBL1775075 | — | — | 1 | - |
| CHEMBL1775076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL1775071 | — | IC50 | = | 9690.0 | nM | 5.01 |
| CHEMBL1775067 | — | IC50 | = | 14880.0 | nM | 4.83 |
| CHEMBL529177 | — | IC50 | = | 16120.0 | nM | 4.79 |
| CHEMBL1775068 | — | IC50 | - | — | - | |
| CHEMBL1775069 | — | IC50 | - | — | - | |
| CHEMBL1775070 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775072 | — | IC50 | - | — | - | |
| CHEMBL1775073 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775074 | — | IC50 | - | — | - | |
| CHEMBL1775075 | — | IC50 | - | — | - | |
| CHEMBL1775076 | — | IC50 | - | — | - |