Assay Detail
Functional
CHEMBL1776673
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by FACS-based assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.06 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1290314 | — | — | 1 | 7.16 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.01 |
| CHEMBL1774611 | — | — | 1 | 6.30 |
| CHEMBL1774609 | — | — | 1 | 6.30 |
| CHEMBL1774607 | — | — | 1 | 6.30 |
| CHEMBL1289100 | — | — | 1 | 6.16 |
| CHEMBL236696 | — | — | 1 | 6.05 |
| CHEMBL1774606 | — | — | 1 | 6.00 |
| CHEMBL31000 | — | — | 1 | 6.00 |
| CHEMBL1774605 | — | — | 1 | 5.96 |
| CHEMBL1774604 | — | — | 1 | 5.82 |
| CHEMBL1774608 | — | — | 1 | 5.77 |
| CHEMBL1774610 | — | — | 1 | 5.51 |
| CHEMBL1774603 | — | — | 1 | 5.42 |
| CHEMBL1774602 | — | — | 1 | 5.14 |
| CHEMBL106509 | DEHYDROZINGERONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1290314 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1774611 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1774609 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1774607 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1289100 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL236696 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1774606 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL31000 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1774605 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1774604 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1774608 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1774610 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1774603 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1774602 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL106509 | DEHYDROZINGERONE | IC50 | > | 20000.0 | nM | - |