Assay Detail
Functional
CHEMBL1776795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.80 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774901 | — | — | 1 | 8.40 |
| CHEMBL1774903 | — | — | 1 | 8.10 |
| CHEMBL1774900 | — | — | 1 | 7.89 |
| CHEMBL1774892 | — | — | 1 | 7.85 |
| CHEMBL1774899 | — | — | 1 | 7.70 |
| CHEMBL1774891 | — | — | 1 | 7.58 |
| CHEMBL1774902 | — | — | 1 | 7.29 |
| CHEMBL1774893 | — | — | 1 | 7.27 |
| CHEMBL1774890 | — | — | 1 | 6.96 |
| CHEMBL1774887 | — | — | 1 | 6.96 |
| CHEMBL1774898 | — | — | 1 | 6.72 |
| CHEMBL1774886 | — | — | 1 | 6.72 |
| CHEMBL1774897 | — | — | 1 | 6.48 |
| CHEMBL1774896 | — | — | 1 | 6.46 |
| CHEMBL1774894 | — | — | 1 | 6.42 |
| CHEMBL1774895 | — | — | 1 | 5.89 |
| CHEMBL1774888 | — | — | 1 | 5.68 |
| CHEMBL1774882 | — | — | 1 | 5.46 |
| CHEMBL1774884 | — | — | 1 | 5.31 |
| CHEMBL1774889 | — | — | 1 | 4.89 |
| CHEMBL1774885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774901 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1774903 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1774900 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1774892 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1774899 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1774891 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1774902 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1774893 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1774890 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1774887 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1774898 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1774886 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1774897 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1774896 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1774894 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1774895 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1774888 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1774882 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1774884 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1774889 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1774885 | — | IC50 | > | 13000.0 | nM | - |