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Assay Detail

CHEMBL1776797

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-UDP from chimpanzee P2Y14 receptor expressed in HEK293 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Pan troglodytes
Cell Type HEK293
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14.
Gauthier JY, Belley M, Deschênes D, Fournier JF, Gagné S, Gareau Y, Hamel M, Hénault M, Hyjazie H, Kargman S, Lavallée G, Levesque JF, Li L, Mamane Y, Mancini J, Morin N, Mulrooney E, Robichaud J, Thérien M, Tranmer G, Wang Z, Wu J, Black WC.
Bioorg Med Chem Lett (2011) 21 : 2836 -2839
PubMed 21507640 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 7.34 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1774903 1 8.40
CHEMBL1774899 1 8.15
CHEMBL1774901 1 8.00
CHEMBL1774898 1 7.89
CHEMBL1774900 1 7.85
CHEMBL1774892 1 7.85
CHEMBL1774891 1 7.80
CHEMBL1774902 1 7.68
CHEMBL1774890 1 7.68
CHEMBL1774886 1 7.54
CHEMBL1774893 1 7.54
CHEMBL1774897 1 7.50
CHEMBL1774887 1 7.38
CHEMBL1774896 1 7.27
CHEMBL1774894 1 6.96
CHEMBL1774882 1 6.80
CHEMBL1774895 1 6.77
CHEMBL1774888 1 6.47
CHEMBL1774884 1 5.82
CHEMBL1774883 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1774903 Ki = 4.0 nM 8.40
CHEMBL1774899 Ki = 7.0 nM 8.15
CHEMBL1774901 Ki = 10.0 nM 8.00
CHEMBL1774898 Ki = 13.0 nM 7.89
CHEMBL1774900 Ki = 14.0 nM 7.85
CHEMBL1774892 Ki = 14.0 nM 7.85
CHEMBL1774891 Ki = 16.0 nM 7.80
CHEMBL1774902 Ki = 21.0 nM 7.68
CHEMBL1774890 Ki = 21.0 nM 7.68
CHEMBL1774886 Ki = 29.0 nM 7.54
CHEMBL1774893 Ki = 29.0 nM 7.54
CHEMBL1774897 Ki = 32.0 nM 7.50
CHEMBL1774887 Ki = 42.0 nM 7.38
CHEMBL1774896 Ki = 54.0 nM 7.27
CHEMBL1774894 Ki = 110.0 nM 6.96
CHEMBL1774882 Ki = 160.0 nM 6.80
CHEMBL1774895 Ki = 170.0 nM 6.77
CHEMBL1774888 Ki = 340.0 nM 6.47
CHEMBL1774884 Ki = 1500.0 nM 5.82
CHEMBL1774883 Ki = 4000.0 nM 5.40