Assay Detail
Binding
CHEMBL1777073
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Inhibition of LTA4 hydrolase in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 0.5 hrs by ELISA
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.09 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1775107 | — | — | 1 | 7.54 |
| CHEMBL1775105 | — | — | 1 | 6.96 |
| CHEMBL1775091 | — | — | 1 | 6.75 |
| CHEMBL1775104 | — | — | 1 | 6.54 |
| CHEMBL1775092 | — | — | 1 | 6.17 |
| CHEMBL1775089 | — | — | 1 | 6.16 |
| CHEMBL1775103 | — | — | 1 | 6.14 |
| CHEMBL1775099 | — | — | 1 | 6.14 |
| CHEMBL162424 | — | — | 1 | 6.11 |
| CHEMBL1775106 | — | — | 1 | 6.01 |
| CHEMBL1775102 | — | — | 1 | 6.00 |
| CHEMBL1775088 | — | — | 1 | 5.85 |
| CHEMBL1775101 | — | — | 1 | 5.70 |
| CHEMBL1775110 | — | — | 1 | 5.68 |
| CHEMBL1775087 | — | — | 1 | 5.16 |
| CHEMBL1775098 | — | — | 1 | 4.47 |
| CHEMBL1775100 | — | — | 1 | - |
| CHEMBL56367 | NIMESULIDE | 4.0 | 1 | - |
| CHEMBL1775097 | — | — | 1 | - |
| CHEMBL1775096 | — | — | 1 | - |
| CHEMBL1775095 | — | — | 1 | - |
| CHEMBL1775094 | — | — | 1 | - |
| CHEMBL1775093 | — | — | 1 | - |
| CHEMBL1775108 | — | — | 1 | - |
| CHEMBL1775109 | — | — | 1 | - |
| CHEMBL1775090 | — | — | 1 | - |
| CHEMBL1775111 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1775107 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1775105 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1775091 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1775104 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1775092 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1775089 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1775103 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1775099 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL162424 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1775106 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1775102 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL1775088 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1775101 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1775110 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1775087 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1775098 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1775100 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL56367 | NIMESULIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775097 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775096 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775095 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775094 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775093 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775108 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775109 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775090 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775111 | — | IC50 | > | 100000.0 | nM | - |