Assay Detail
ADMET
CHEMBL1777121
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Binding affinity to rat serum albumin at 37 degC by surface plasmon resonance assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.02 | 4.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1464 | WARFARIN | 4.0 | 1 | 4.02 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1464 | WARFARIN | Kd | = | 95000.0 | nM | 4.02 |
| CHEMBL473417 | VISMODEGIB | Kd | = | 140000.0 | nM | - |