Assay Detail
Functional
CHEMBL1777184
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHOp |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.72 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.99 |
| CHEMBL1774538 | — | — | 1 | 6.38 |
| CHEMBL1774533 | — | — | 1 | 5.80 |
| CHEMBL1774384 | — | — | 1 | - |
| CHEMBL1774385 | — | — | 1 | - |
| CHEMBL1774386 | — | — | 1 | - |
| CHEMBL1774532 | — | — | 1 | - |
| CHEMBL1774534 | — | — | 1 | - |
| CHEMBL1774535 | — | — | 1 | - |
| CHEMBL1774536 | — | — | 1 | - |
| CHEMBL1774383 | — | — | 1 | - |
| CHEMBL1774539 | — | — | 1 | - |
| CHEMBL1774540 | — | — | 1 | - |
| CHEMBL1774541 | — | — | 1 | - |
| CHEMBL1774542 | — | — | 1 | - |
| CHEMBL1773087 | — | — | 1 | - |
| CHEMBL1774537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26 | SULPIRIDE | IC50 | = | 10.28 | nM | 7.99 |
| CHEMBL1774538 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL1774533 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1774384 | — | IC50 | - | — | - | |
| CHEMBL1774385 | — | IC50 | - | — | - | |
| CHEMBL1774386 | — | IC50 | - | — | - | |
| CHEMBL1774532 | — | IC50 | - | — | - | |
| CHEMBL1774534 | — | IC50 | - | — | - | |
| CHEMBL1774535 | — | IC50 | - | — | - | |
| CHEMBL1774536 | — | IC50 | - | — | - | |
| CHEMBL1774383 | — | IC50 | - | — | - | |
| CHEMBL1774539 | — | IC50 | - | — | - | |
| CHEMBL1774540 | — | IC50 | - | — | - | |
| CHEMBL1774541 | — | IC50 | - | — | - | |
| CHEMBL1774542 | — | IC50 | - | — | - | |
| CHEMBL1773087 | — | IC50 | - | — | - | |
| CHEMBL1774537 | — | IC50 | - | — | - |