Assay Detail
Binding
CHEMBL1777256
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Inhibition of mouse recombinant SPHK2 expressed in baculovirus-infected Sf9 cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 4.98 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774571 | — | — | 1 | 5.82 |
| CHEMBL1774573 | — | — | 1 | 5.52 |
| CHEMBL1774587 | — | — | 1 | 5.38 |
| CHEMBL1774562 | — | — | 1 | 5.34 |
| CHEMBL1774570 | — | — | 1 | 5.30 |
| CHEMBL1774572 | — | — | 1 | 5.30 |
| CHEMBL1774574 | — | — | 1 | 5.28 |
| CHEMBL1774588 | — | — | 1 | 5.22 |
| CHEMBL1774560 | — | — | 1 | 5.16 |
| CHEMBL1774553 | — | — | 1 | 5.12 |
| CHEMBL1774585 | — | — | 1 | 5.10 |
| CHEMBL1774568 | — | — | 1 | 5.00 |
| CHEMBL1774559 | — | — | 1 | 4.92 |
| CHEMBL1774569 | — | — | 1 | 4.92 |
| CHEMBL1774565 | — | — | 1 | 4.82 |
| CHEMBL1774566 | — | — | 1 | 4.75 |
| CHEMBL1774586 | — | — | 1 | 4.70 |
| CHEMBL1774564 | — | — | 1 | 4.60 |
| CHEMBL1774563 | — | — | 1 | 4.58 |
| CHEMBL583979 | — | — | 1 | 4.51 |
| CHEMBL1076555 | — | — | 1 | 4.48 |
| CHEMBL1774556 | — | — | 1 | 4.42 |
| CHEMBL1774567 | — | — | 1 | 4.40 |
| CHEMBL1774561 | — | — | 1 | - |
| CHEMBL1774558 | — | — | 1 | - |
| CHEMBL1774557 | — | — | 1 | - |
| CHEMBL1774555 | — | — | 1 | - |
| CHEMBL1774554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774571 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL1774573 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL1774587 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL1774562 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL1774570 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL1774572 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL1774574 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL1774588 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL1774560 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL1774553 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL1774585 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL1774568 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1774559 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1774569 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1774565 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL1774566 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1774586 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL1774564 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL1774563 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL583979 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL1076555 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL1774556 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL1774567 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1774561 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL1774558 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1774557 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1774555 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1774554 | — | Ki | > | 100000.0 | nM | - |