Assay Detail
Binding
CHEMBL1777433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assay
19
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.52 | 6.44 |
| Inhibition | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314360 | — | — | 1 | 6.44 |
| CHEMBL565883 | — | — | 2 | 6.10 |
| CHEMBL1378043 | — | — | 2 | 5.72 |
| CHEMBL1774310 | — | — | 2 | 5.54 |
| CHEMBL1774309 | — | — | 2 | 5.28 |
| CHEMBL1324382 | — | — | 2 | 5.26 |
| CHEMBL1774311 | — | — | 2 | 5.24 |
| CHEMBL1774308 | — | — | 2 | 5.10 |
| CHEMBL1774307 | — | — | 2 | 5.04 |
| CHEMBL1774306 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314360 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL565883 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1378043 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1774310 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1774309 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1324382 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1774311 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1774308 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1774307 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1774306 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1774306 | — | Inhibition | - | % | - | |
| CHEMBL565883 | — | Inhibition | - | % | - | |
| CHEMBL1324382 | — | Inhibition | - | % | - | |
| CHEMBL1774307 | — | Inhibition | - | % | - | |
| CHEMBL1774308 | — | Inhibition | - | % | - | |
| CHEMBL1774309 | — | Inhibition | - | % | - | |
| CHEMBL1774310 | — | Inhibition | - | % | - | |
| CHEMBL1774311 | — | Inhibition | - | % | - | |
| CHEMBL1378043 | — | Inhibition | - | % | - |