Assay Detail
Binding
CHEMBL1777435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assay
19
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.64 | 6.96 |
| Inhibition | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314360 | — | — | 1 | 6.96 |
| CHEMBL1774309 | — | — | 2 | 6.07 |
| CHEMBL1378043 | — | — | 2 | 5.64 |
| CHEMBL1774310 | — | — | 2 | 5.57 |
| CHEMBL1324382 | — | — | 2 | 5.55 |
| CHEMBL1774311 | — | — | 2 | 5.35 |
| CHEMBL1774306 | — | — | 2 | 5.33 |
| CHEMBL565883 | — | — | 2 | 5.27 |
| CHEMBL1774307 | — | — | 2 | 5.01 |
| CHEMBL1774308 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314360 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1774309 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1378043 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1774310 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1324382 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1774311 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1774306 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL565883 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1774307 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1378043 | — | Inhibition | - | % | - | |
| CHEMBL1774311 | — | Inhibition | - | % | - | |
| CHEMBL1774310 | — | Inhibition | - | % | - | |
| CHEMBL1774309 | — | Inhibition | - | % | - | |
| CHEMBL1774308 | — | Inhibition | - | % | - | |
| CHEMBL1774307 | — | Inhibition | - | % | - | |
| CHEMBL1324382 | — | Inhibition | - | % | - | |
| CHEMBL565883 | — | Inhibition | - | % | - | |
| CHEMBL1774306 | — | Inhibition | - | % | - | |
| CHEMBL1774308 | — | IC50 | > | 10000.0 | nM | - |