Assay Detail
Functional
CHEMBL1777604
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Inhibition of glucose induced insulin secretion from rat Pancreatic islet assessed as percentage of residual insulin release
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pancreatic islet |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.05 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112668 | — | — | 1 | 6.26 |
| CHEMBL1774479 | — | — | 1 | 5.24 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.74 |
| CHEMBL1774464 | — | — | 1 | 4.72 |
| CHEMBL1774471 | — | — | 1 | 4.30 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112668 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1774479 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1774464 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL1774471 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | = | 202300.0 | nM | - |