Assay Detail
Binding
CHEMBL1780284
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Inhibition of neutral endopeptidase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.48 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1778532 | — | — | 1 | 9.52 |
| CHEMBL1778534 | — | — | 1 | 9.52 |
| CHEMBL42583 | SAMPATRILAT | 2.0 | 1 | 9.22 |
| CHEMBL1778530 | — | — | 1 | 9.22 |
| CHEMBL1778536 | — | — | 1 | 8.72 |
| CHEMBL1778531 | — | — | 1 | 8.32 |
| CHEMBL1778533 | — | — | 1 | 8.30 |
| CHEMBL1778535 | — | — | 1 | 8.22 |
| CHEMBL1778529 | — | — | 1 | 8.15 |
| CHEMBL434492 | CANDOXATRILAT | 2.0 | 1 | 8.11 |
| CHEMBL1778528 | — | — | 1 | 7.70 |
| CHEMBL1778527 | — | — | 1 | 7.66 |
| CHEMBL1778526 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1778532 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1778534 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL42583 | SAMPATRILAT | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1778530 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1778536 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1778531 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1778533 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1778535 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1778529 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL434492 | CANDOXATRILAT | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL1778528 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1778527 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1778526 | — | IC50 | = | 28.0 | nM | 7.55 |