Assay Detail
Functional
CHEMBL1780358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of cholestane saponins as mimics of OSW-1 and their cytotoxic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.72 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.22 |
| CHEMBL1779448 | — | — | 1 | 7.64 |
| CHEMBL1779450 | — | — | 1 | 7.30 |
| CHEMBL1779449 | — | — | 1 | - |
| CHEMBL1779451 | — | — | 1 | - |
| CHEMBL1779452 | — | — | 1 | - |
| CHEMBL1779453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1779448 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1779450 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1779449 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1779451 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1779452 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1779453 | — | IC50 | > | 10000.0 | nM | - |