Assay Detail
Functional
CHEMBL1780401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Gal4-fussed PPARdelta expressed in human HEK293 cells by reporter gene assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.11 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1779473 | — | — | 1 | 6.96 |
| CHEMBL1222408 | — | — | 1 | 6.92 |
| CHEMBL270587 | — | — | 1 | 6.68 |
| CHEMBL1779480 | — | — | 1 | 6.52 |
| CHEMBL255392 | — | — | 1 | 6.44 |
| CHEMBL1779481 | — | — | 1 | 6.24 |
| CHEMBL1779482 | — | — | 1 | 6.10 |
| CHEMBL1779478 | — | — | 1 | 5.85 |
| CHEMBL1779479 | — | — | 1 | 5.85 |
| CHEMBL1779476 | — | — | 1 | 5.39 |
| CHEMBL1779474 | — | — | 1 | 5.32 |
| CHEMBL255593 | — | — | 1 | 5.09 |
| CHEMBL1779475 | — | — | 1 | - |
| CHEMBL1779477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1779473 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1222408 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL270587 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1779480 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL255392 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1779481 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1779482 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1779478 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1779479 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1779476 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1779474 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL255593 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1779475 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1779477 | — | EC50 | > | 10000.0 | nM | - |