Assay Detail
Functional
CHEMBL1780402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Gal4-fussed PPARgamma expressed in human HEK293 cells by reporter gene assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.91 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270587 | — | — | 1 | 6.47 |
| CHEMBL1779478 | — | — | 1 | 6.34 |
| CHEMBL1779476 | — | — | 1 | 6.15 |
| CHEMBL1779479 | — | — | 1 | 6.11 |
| CHEMBL1222408 | — | — | 1 | 6.09 |
| CHEMBL1779481 | — | — | 1 | 6.08 |
| CHEMBL1779480 | — | — | 1 | 6.04 |
| CHEMBL1779482 | — | — | 1 | 6.00 |
| CHEMBL1779473 | — | — | 1 | 5.36 |
| CHEMBL1779474 | — | — | 1 | 5.34 |
| CHEMBL255392 | — | — | 1 | 5.02 |
| CHEMBL255593 | — | — | 1 | - |
| CHEMBL1779475 | — | — | 1 | - |
| CHEMBL1779477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270587 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1779478 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1779476 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1779479 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1222408 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1779481 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1779480 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1779482 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL1779473 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1779474 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL255392 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL255593 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1779475 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1779477 | — | EC50 | > | 10000.0 | nM | - |