Assay Detail
Functional
CHEMBL1780533
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Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 3 days
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ketonethiosemicarbazones: structure-activity relationships for their melanogenesis inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.49 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1779101 | — | — | 1 | 6.10 |
| CHEMBL1778989 | — | — | 1 | 6.08 |
| CHEMBL1779100 | — | — | 1 | 5.72 |
| CHEMBL1779099 | — | — | 1 | 5.70 |
| CHEMBL90023 | — | — | 1 | 5.70 |
| CHEMBL74689 | PHENYL(METHYL)THIOSEMICARBAZONE | — | 1 | 5.64 |
| CHEMBL1779105 | — | — | 1 | 5.64 |
| CHEMBL1778990 | — | — | 1 | 5.58 |
| CHEMBL223505 | — | — | 1 | 5.57 |
| CHEMBL93125 | — | — | 1 | 5.54 |
| CHEMBL1779098 | — | — | 1 | 5.43 |
| CHEMBL1779104 | — | — | 1 | 5.41 |
| CHEMBL91344 | — | — | 1 | 5.40 |
| CHEMBL1269809 | BENZOPHENONE-THIOSEMICARBAZONE | — | 1 | 5.31 |
| CHEMBL1779106 | — | — | 1 | 5.21 |
| CHEMBL1779103 | — | — | 1 | 5.09 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.16 |
| CHEMBL1779102 | — | — | 1 | - |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1779101 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1778989 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1779100 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1779099 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL90023 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL74689 | PHENYL(METHYL)THIOSEMICARBAZONE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1779105 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1778990 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL223505 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL93125 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1779098 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1779104 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL91344 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1269809 | BENZOPHENONE-THIOSEMICARBAZONE | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1779106 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1779103 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1779102 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL232202 | ARBUTIN | IC50 | = | 180000.0 | nM | - |