Assay Detail
Binding
CHEMBL1780728
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Inhibition of MK2 pretreated for 30 mins before substrate addition measured after 2 hrs by IMAP assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
MAP kinase-activated protein kinase 2 (CHEMBL2208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based lead identification of ATP-competitive MK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.49 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1738702 | — | — | 1 | 8.40 |
| CHEMBL1779361 | — | — | 1 | 8.22 |
| CHEMBL1738780 | — | — | 1 | 7.55 |
| CHEMBL226403 | — | — | 1 | 7.31 |
| CHEMBL1779517 | — | — | 1 | 6.82 |
| CHEMBL1779516 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1738702 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1779361 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1738780 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL226403 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1779517 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL1779516 | — | EC50 | = | 234.0 | nM | 6.63 |