Assay Detail

CHEMBL1780895

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Functional

Antiinflammatory activity in human PBMC cells assessed as inhibition of LPS-induced TNFalpha production treated 30 mins before LPS challenge measured after 4 hrs by ELISA

ChEMBL ↗

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Target

PBMC (CHEMBL613107) ↗

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Primary target PBMC

CHEMBL613107

Anchored from Assay target.

Protein identity PBMC

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PBMC
Confidence	1 — Organism
Curated By	Autocuration

Target

PBMC (CHEMBL613107) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Structure-based lead identification of ATP-competitive MK2 inhibitors.

Barf T, Kaptein A, de Wilde S, van der Heijden R, van Someren R, Demont D, Schultz-Fademrecht C, Versteegh J, van Zeeland M, Seegers N, Kazemier B, van de Kar B, van Hoek M, de Roos J, Klop H, Smeets R, Hofstra C, Hornberg J, Oubrie A.
Bioorg Med Chem Lett (2011) 21 : 3818 -3822
PubMed 21565500 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.58	6.58

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1738702	—	—	1	6.58

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1738702	—	EC50	=	260.0	nM	6.58