Assay Detail
Binding
CHEMBL1780990
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Un-competitive inhibition of metallo-beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) using benzylpenicillin as substrate by 96-well plate assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 3.15 | 3.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1778128 | — | — | 1 | 3.39 |
| CHEMBL1236744 | — | — | 1 | 3.37 |
| CHEMBL1778129 | — | — | 1 | 3.30 |
| CHEMBL1778130 | — | — | 1 | 3.17 |
| CHEMBL597369 | — | — | 1 | 3.11 |
| CHEMBL590987 | — | — | 1 | 3.10 |
| CHEMBL1778131 | — | — | 1 | 3.05 |
| CHEMBL598389 | — | — | 1 | 2.93 |
| CHEMBL1778132 | — | — | 1 | 2.92 |
| CHEMBL1778133 | — | — | 1 | - |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1778128 | — | Ki | = | 410000.0 | nM | 3.39 |
| CHEMBL1236744 | — | Ki | = | 430000.0 | nM | 3.37 |
| CHEMBL1778129 | — | Ki | = | 500000.0 | nM | 3.30 |
| CHEMBL1778130 | — | Ki | = | 680000.0 | nM | 3.17 |
| CHEMBL597369 | — | Ki | = | 780000.0 | nM | 3.11 |
| CHEMBL590987 | — | Ki | = | 790000.0 | nM | 3.10 |
| CHEMBL1778131 | — | Ki | = | 900000.0 | nM | 3.05 |
| CHEMBL598389 | — | Ki | = | 1180000.0 | nM | 2.93 |
| CHEMBL1778132 | — | Ki | = | 1200000.0 | nM | 2.92 |
| CHEMBL1778133 | — | Ki | > | 2000000.0 | nM | - |
| CHEMBL1560 | CAPTOPRIL | Ki | > | 2000000.0 | nM | - |