Assay Detail
Binding
CHEMBL1781264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant aldose reductase 2 expressed in Escherichia coli BL21 after 10 mins by spectrophotometry analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.12 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363387 | LIDORESTAT | 2.0 | 1 | 8.30 |
| CHEMBL1235556 | — | — | 1 | 8.15 |
| CHEMBL1780235 | — | — | 1 | 8.10 |
| CHEMBL1780236 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363387 | LIDORESTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1235556 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1780235 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1780236 | — | IC50 | = | 12.0 | nM | 7.92 |