Assay Detail
Binding
CHEMBL1781265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant aldose reductase 1 after 10 mins by spectrophotometry analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.57 | 4.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363387 | LIDORESTAT | 2.0 | 1 | 4.57 |
| CHEMBL1235556 | — | — | 1 | - |
| CHEMBL1780235 | — | — | 1 | - |
| CHEMBL1780236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363387 | LIDORESTAT | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1235556 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1780235 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1780236 | — | IC50 | > | 100000.0 | nM | - |