Assay Detail

CHEMBL1781288

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Binding

Inhibition of aurora A

ChEMBL ↗

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Target

Aurora kinase A (CHEMBL4722) ↗

Open DB target context

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Primary target Aurora kinase A

CHEMBL4722

Anchored from Assay target.

Protein identity Aurora kinase A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Aurora kinase A (CHEMBL4722) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: selective Aurora A kinase inhibitors.

Ando R, Ikegami H, Sakiyama M, Ooike S, Hayashi M, Fujino Y, Abe D, Nakamura H, Mishina T, Kato H, Iwase Y, Tomozane H, Morioka M.
Bioorg Med Chem Lett (2010) 20 : 4709 -4711
PubMed 20573509 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.22	9.22
IC50	1	7.85	7.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL572878	TOZASERTIB	2.0	1	9.22
CHEMBL482968	ENMD-2076	2.0	1	7.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL572878	TOZASERTIB	Ki	=	0.6	nM	9.22
CHEMBL482968	ENMD-2076	IC50	=	14.0	nM	7.85