Assay Detail
Functional
CHEMBL1781407
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Cytotoxicity against human KB cells after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.06 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | — | 1 | 8.11 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 8.05 |
| CHEMBL1778157 | — | — | 1 | 7.30 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.25 |
| CHEMBL28941 | — | — | 1 | 7.19 |
| CHEMBL1778163 | — | — | 1 | 5.68 |
| CHEMBL1778158 | SINOLIGNAN A | — | 1 | 5.06 |
| CHEMBL503644 | — | — | 1 | 5.03 |
| CHEMBL1778162 | — | — | 1 | 5.02 |
| CHEMBL487214 | DEHYDROPODOPHYLLOTOXIN | — | 1 | 5.01 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.00 |
| CHEMBL521394 | — | — | 1 | 4.07 |
| CHEMBL1778160 | ISOPICROPODOPHYLLONE | — | 1 | - |
| CHEMBL1778161 | — | — | 1 | - |
| CHEMBL99342 | — | — | 1 | - |
| CHEMBL329250 | 6,7-O,O-DEMETHYLENEPODOPHYLLOTOXIN | — | 1 | - |
| CHEMBL1778159 | SINOLIGNAN B | — | 1 | - |
| CHEMBL1778164 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL1778157 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL61 | PODOFILOX | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL28941 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1778163 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL1778158 | SINOLIGNAN A | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL503644 | — | IC50 | = | 9250.0 | nM | 5.03 |
| CHEMBL1778162 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL487214 | DEHYDROPODOPHYLLOTOXIN | IC50 | = | 9790.0 | nM | 5.01 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL521394 | — | IC50 | = | 84700.0 | nM | 4.07 |
| CHEMBL1778160 | ISOPICROPODOPHYLLONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1778161 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL99342 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL329250 | 6,7-O,O-DEMETHYLENEPODOPHYLLOTOXIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL1778159 | SINOLIGNAN B | IC50 | > | 100000.0 | nM | - |
| CHEMBL1778164 | — | IC50 | > | 100000.0 | nM | - |