Assay Detail
Binding
CHEMBL1781414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human D2 receptor expressed in HEK cells
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (σ) receptor ligands modulates off-target activity and subtype selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.77 | 9.00 |
| IC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.00 |
| CHEMBL1779058 | — | — | 1 | 5.76 |
| CHEMBL64260 | — | — | 1 | 5.54 |
| CHEMBL1779059 | — | — | 1 | - |
| CHEMBL1779060 | — | — | 1 | - |
| CHEMBL521582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1779058 | — | Ki | = | 1724.0 | nM | 5.76 |
| CHEMBL64260 | — | Ki | = | 2850.0 | nM | 5.54 |
| CHEMBL1779059 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1779060 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL521582 | — | IC50 | > | 10000.0 | nM | - |