Assay Detail
Binding
CHEMBL1781668
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Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.42 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551884 | — | — | 1 | 5.77 |
| CHEMBL564017 | — | — | 1 | 5.70 |
| CHEMBL563351 | — | — | 1 | 5.66 |
| CHEMBL558072 | — | — | 1 | 5.66 |
| CHEMBL29097 | — | — | 1 | 5.62 |
| CHEMBL563546 | — | — | 1 | 5.57 |
| CHEMBL558141 | — | — | 1 | 5.54 |
| CHEMBL561284 | — | — | 1 | 5.39 |
| CHEMBL551479 | — | — | 1 | 5.38 |
| CHEMBL551480 | — | — | 1 | 5.34 |
| CHEMBL559752 | — | — | 1 | 5.15 |
| CHEMBL549723 | — | — | 1 | 5.06 |
| CHEMBL1780184 | — | — | 1 | 5.03 |
| CHEMBL557342 | — | — | 1 | 5.03 |
| CHEMBL1780185 | — | — | 1 | - |
| CHEMBL1780186 | — | — | 1 | - |
| CHEMBL314360 | — | — | 1 | - |
| CHEMBL562786 | — | — | 1 | - |
| CHEMBL561006 | — | — | 1 | - |
| CHEMBL563311 | — | — | 1 | - |
| CHEMBL552347 | — | — | 1 | - |
| CHEMBL560484 | — | — | 1 | - |
| CHEMBL560205 | — | — | 1 | - |
| CHEMBL550332 | — | — | 1 | - |
| CHEMBL551420 | — | — | 1 | - |
| CHEMBL1780187 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551884 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL564017 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL563351 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL558072 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL29097 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL563546 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL558141 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL561284 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL551479 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL551480 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL559752 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL549723 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1780184 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL557342 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1780185 | — | IC50 | - | — | - | |
| CHEMBL1780186 | — | IC50 | - | — | - | |
| CHEMBL314360 | — | IC50 | - | — | - | |
| CHEMBL562786 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL561006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL563311 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL552347 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL560484 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL560205 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL550332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL551420 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1780187 | — | IC50 | > | 10000.0 | nM | - |