Assay Detail
Binding
CHEMBL1781670
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Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presence of exogenous arachidonic acid
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.81 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314360 | — | — | 1 | 7.10 |
| CHEMBL29097 | — | — | 1 | 7.05 |
| CHEMBL1780187 | — | — | 1 | 6.10 |
| CHEMBL563351 | — | — | 1 | 6.05 |
| CHEMBL551479 | — | — | 1 | 5.96 |
| CHEMBL558072 | — | — | 1 | 5.85 |
| CHEMBL563546 | — | — | 1 | 5.85 |
| CHEMBL551884 | — | — | 1 | 5.82 |
| CHEMBL564017 | — | — | 1 | 5.80 |
| CHEMBL561284 | — | — | 1 | 5.80 |
| CHEMBL563311 | — | — | 1 | 5.80 |
| CHEMBL551480 | — | — | 1 | 5.70 |
| CHEMBL559752 | — | — | 1 | 5.70 |
| CHEMBL558141 | — | — | 1 | 5.52 |
| CHEMBL549723 | — | — | 1 | 5.32 |
| CHEMBL560484 | — | — | 1 | 5.32 |
| CHEMBL550332 | — | — | 1 | 5.32 |
| CHEMBL557342 | — | — | 1 | 5.28 |
| CHEMBL552347 | — | — | 1 | 5.02 |
| CHEMBL551420 | — | — | 1 | - |
| CHEMBL1780186 | — | — | 1 | - |
| CHEMBL1780185 | — | — | 1 | - |
| CHEMBL1780184 | — | — | 1 | - |
| CHEMBL560205 | — | — | 1 | - |
| CHEMBL561006 | — | — | 1 | - |
| CHEMBL562786 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314360 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL29097 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1780187 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL563351 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL551479 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL558072 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL563546 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL551884 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL564017 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL561284 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL563311 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL551480 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL559752 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL558141 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL549723 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL560484 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL550332 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL557342 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL552347 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL551420 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1780186 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1780185 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1780184 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL560205 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL561006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL562786 | — | IC50 | > | 10000.0 | nM | - |