Assay Detail
Binding
CHEMBL1781770
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Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.15 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1779202 | — | — | 1 | 8.82 |
| CHEMBL1779200 | — | — | 1 | 8.74 |
| CHEMBL1779193 | — | — | 1 | 8.43 |
| CHEMBL1779192 | — | — | 1 | 8.10 |
| CHEMBL1779198 | — | — | 1 | 7.94 |
| CHEMBL1779194 | — | — | 1 | 7.94 |
| CHEMBL1779197 | — | — | 1 | 7.73 |
| CHEMBL1779195 | — | — | 1 | 7.58 |
| CHEMBL1779201 | — | — | 1 | 7.57 |
| CHEMBL1779196 | — | — | 1 | 7.48 |
| CHEMBL1779199 | — | — | 1 | 7.43 |
| CHEMBL1779191 | — | — | 1 | 7.40 |
| CHEMBL1779190 | — | — | 1 | 7.10 |
| CHEMBL1779189 | — | — | 1 | 7.00 |
| CHEMBL1779187 | — | — | 1 | 6.18 |
| CHEMBL1779186 | — | — | 1 | 6.11 |
| CHEMBL1779185 | — | — | 1 | 6.07 |
| CHEMBL1779097 | — | — | 1 | 5.87 |
| CHEMBL1779183 | — | — | 1 | 5.68 |
| CHEMBL1779184 | — | — | 1 | 5.61 |
| CHEMBL1779188 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1779202 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1779200 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1779193 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1779192 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1779198 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL1779194 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL1779197 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL1779195 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL1779201 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1779196 | — | IC50 | = | 33.4 | nM | 7.48 |
| CHEMBL1779199 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL1779191 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1779190 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1779189 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1779187 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1779186 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1779185 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1779097 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL1779183 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL1779184 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL1779188 | — | IC50 | = | 3470.0 | nM | 5.46 |