Assay Detail
Functional
CHEMBL1781772
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Cytotoxicity against human KARPAS299 cells expressing NPM-ALK after 96 hrs by cell counting kit-8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.74 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1779202 | — | — | 1 | 7.67 |
| CHEMBL1779200 | — | — | 1 | 7.47 |
| CHEMBL1779201 | — | — | 1 | 7.32 |
| CHEMBL1779192 | — | — | 1 | 7.22 |
| CHEMBL1779193 | — | — | 1 | 7.06 |
| CHEMBL1779198 | — | — | 1 | 6.94 |
| CHEMBL1779197 | — | — | 1 | 6.87 |
| CHEMBL1779199 | — | — | 1 | 6.58 |
| CHEMBL1779196 | — | — | 1 | 6.48 |
| CHEMBL1779194 | — | — | 1 | 6.40 |
| CHEMBL1779191 | — | — | 1 | 6.31 |
| CHEMBL1779190 | — | — | 1 | 6.24 |
| CHEMBL1779189 | — | — | 1 | 6.17 |
| CHEMBL1779195 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1779202 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL1779200 | — | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL1779201 | — | IC50 | = | 47.9 | nM | 7.32 |
| CHEMBL1779192 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1779193 | — | IC50 | = | 87.5 | nM | 7.06 |
| CHEMBL1779198 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1779197 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL1779199 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL1779196 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL1779194 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL1779191 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1779190 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1779189 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1779195 | — | IC50 | = | 2306.0 | nM | 5.64 |