Assay Detail
Binding
CHEMBL1781816
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Inhibition of mouse Oat1 expressed in Xenopus oocytes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.16 | 4.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL461 | HIPPURIC ACID | — | 1 | 4.25 |
| CHEMBL607712 | 4-HYDROXYPHENYLPYRUVIC ACID | — | 1 | 4.14 |
| CHEMBL1162488 | PHENYLPYRUVATE | — | 1 | 4.10 |
| CHEMBL1162497 | — | — | 1 | - |
| CHEMBL1162494 | N-ACETYLASPARTIC ACID | — | 1 | - |
| CHEMBL1162489 | — | — | 1 | - |
| CHEMBL1615211 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL461 | HIPPURIC ACID | Ki | = | 55600.0 | nM | 4.25 |
| CHEMBL607712 | 4-HYDROXYPHENYLPYRUVIC ACID | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL1162488 | PHENYLPYRUVATE | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL1162497 | — | Ki | = | 3320000.0 | nM | - |
| CHEMBL1162494 | N-ACETYLASPARTIC ACID | Ki | = | 840000.0 | nM | - |
| CHEMBL1162489 | — | Ki | = | 223000.0 | nM | - |
| CHEMBL1615211 | — | Ki | = | 840000.0 | nM | - |