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Assay Detail

CHEMBL1781852

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mouse liver fructose-1,6-bisphosphatase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fructose-1,6-bisphosphatase 1 (CHEMBL5360)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
Hebeisen P, Haap W, Kuhn B, Mohr P, Wessel HP, Zutter U, Kirchner S, Ruf A, Benz J, Joseph C, Alvarez-Sánchez R, Gubler M, Schott B, Benardeau A, Tozzo E, Kitas E.
Bioorg Med Chem Lett (2011) 21 : 3237 -3242
PubMed 21550236 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.35 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1778447 1 6.00
CHEMBL1778449 1 5.82
CHEMBL1778448 1 5.80
CHEMBL1778445 1 5.77
CHEMBL1738935 1 5.58
CHEMBL1778443 1 5.48
CHEMBL1778556 1 5.46
CHEMBL1778454 1 5.46
CHEMBL1778450 1 5.43
CHEMBL1778555 1 5.40
CHEMBL1778558 1 5.40
CHEMBL1778444 1 5.35
CHEMBL1778442 1 5.30
CHEMBL595149 1 5.24
CHEMBL1778453 1 5.22
CHEMBL1778557 1 5.16
CHEMBL1778559 1 5.14
CHEMBL1778446 1 5.10
CHEMBL1778560 1 5.08
CHEMBL1778451 1 5.05
CHEMBL1778441 1 4.92
CHEMBL1778452 1 4.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1778447 IC50 = 1000.0 nM 6.00
CHEMBL1778449 IC50 = 1500.0 nM 5.82
CHEMBL1778448 IC50 = 1600.0 nM 5.80
CHEMBL1778445 IC50 = 1700.0 nM 5.77
CHEMBL1738935 IC50 = 2600.0 nM 5.58
CHEMBL1778443 IC50 = 3300.0 nM 5.48
CHEMBL1778556 IC50 = 3500.0 nM 5.46
CHEMBL1778454 IC50 = 3500.0 nM 5.46
CHEMBL1778450 IC50 = 3700.0 nM 5.43
CHEMBL1778555 IC50 = 4000.0 nM 5.40
CHEMBL1778558 IC50 = 4000.0 nM 5.40
CHEMBL1778444 IC50 = 4500.0 nM 5.35
CHEMBL1778442 IC50 = 5000.0 nM 5.30
CHEMBL595149 IC50 = 5790.0 nM 5.24
CHEMBL1778453 IC50 = 6000.0 nM 5.22
CHEMBL1778557 IC50 = 7000.0 nM 5.16
CHEMBL1778559 IC50 = 7300.0 nM 5.14
CHEMBL1778446 IC50 = 8000.0 nM 5.10
CHEMBL1778560 IC50 = 8300.0 nM 5.08
CHEMBL1778451 IC50 = 9000.0 nM 5.05
CHEMBL1778441 IC50 = 12000.0 nM 4.92
CHEMBL1778452 IC50 = 30000.0 nM 4.52