Assay Detail
Binding
CHEMBL1785171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELISA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.33 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438139 | ROCAGLAMIDE | — | 1 | 7.12 |
| CHEMBL1782240 | — | — | 1 | 5.54 |
| CHEMBL1782239 | COCHINENSOXANTHONE | — | 1 | - |
| CHEMBL323197 | MANGOSTIN | — | 1 | - |
| CHEMBL260553 | — | — | 1 | - |
| CHEMBL1782241 | COCHINCHINONE A | — | 1 | - |
| CHEMBL1782242 | — | — | 1 | - |
| CHEMBL465553 | — | — | 1 | - |
| CHEMBL1782243 | — | — | 1 | - |
| CHEMBL1782244 | — | — | 1 | - |
| CHEMBL1782238 | COCHINCHINOXANTHONE | — | 1 | - |
| CHEMBL1782245 | — | — | 1 | - |
| CHEMBL1782059 | — | — | 1 | - |
| CHEMBL1782246 | — | — | 1 | - |
| CHEMBL1782247 | — | — | 1 | - |
| CHEMBL1782248 | — | — | 1 | - |
| CHEMBL1782582 | — | — | 1 | - |
| CHEMBL1782583 | — | — | 1 | - |
| CHEMBL1782584 | — | — | 1 | - |
| CHEMBL464524 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438139 | ROCAGLAMIDE | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1782240 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1782239 | COCHINENSOXANTHONE | IC50 | - | — | - | |
| CHEMBL323197 | MANGOSTIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL260553 | — | IC50 | - | — | - | |
| CHEMBL1782241 | COCHINCHINONE A | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782242 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL465553 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782243 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782244 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782238 | COCHINCHINOXANTHONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782245 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782059 | — | IC50 | - | — | - | |
| CHEMBL1782246 | — | IC50 | - | — | - | |
| CHEMBL1782247 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782248 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782582 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782583 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782584 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL464524 | — | IC50 | > | 10000.0 | nM | - |