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Assay Detail

CHEMBL1785172

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effect on mitochondrial membrane potential in human HT-29 cells after 2 hrs using JC-1 staining by fluorescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.
Ren Y, Matthew S, Lantvit DD, Ninh TN, Chai H, Fuchs JR, Soejarto DD, de Blanco EJ, Swanson SM, Kinghorn AD.
J Nat Prod (2011) 74 : 1117 -1125
PubMed 21428375 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.42 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL388978 STAUROSPORINE 1 8.70
CHEMBL323197 MANGOSTIN 1 6.70
CHEMBL1782244 1 6.05
CHEMBL464524 1 5.85
CHEMBL465553 1 5.75
CHEMBL1782238 COCHINCHINOXANTHONE 1 5.48
CHEMBL1782239 COCHINENSOXANTHONE 1 -
CHEMBL1782584 1 -
CHEMBL1782583 1 -
CHEMBL1782582 1 -
CHEMBL1782248 1 -
CHEMBL1782247 1 -
CHEMBL1782246 1 -
CHEMBL1782059 1 -
CHEMBL1782245 1 -
CHEMBL260553 1 -
CHEMBL1782243 1 -
CHEMBL1782242 1 -
CHEMBL1782241 COCHINCHINONE A 1 -
CHEMBL1782240 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL388978 STAUROSPORINE IC50 = 2.0 nM 8.70
CHEMBL323197 MANGOSTIN IC50 = 200.0 nM 6.70
CHEMBL1782244 IC50 = 900.0 nM 6.05
CHEMBL464524 IC50 = 1400.0 nM 5.85
CHEMBL465553 IC50 = 1800.0 nM 5.75
CHEMBL1782238 COCHINCHINOXANTHONE IC50 = 3300.0 nM 5.48
CHEMBL1782239 COCHINENSOXANTHONE IC50 - -
CHEMBL1782584 IC50 > 10000.0 nM -
CHEMBL1782583 IC50 - -
CHEMBL1782582 IC50 > 10000.0 nM -
CHEMBL1782248 IC50 - -
CHEMBL1782247 IC50 > 10000.0 nM -
CHEMBL1782246 IC50 > 10000.0 nM -
CHEMBL1782059 IC50 > 10000.0 nM -
CHEMBL1782245 IC50 > 10000.0 nM -
CHEMBL260553 IC50 > 10000.0 nM -
CHEMBL1782243 IC50 - -
CHEMBL1782242 IC50 - -
CHEMBL1782241 COCHINCHINONE A IC50 > 10000.0 nM -
CHEMBL1782240 IC50 - -