Assay Detail
Binding
CHEMBL1785218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.70 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782141 | — | — | 1 | 9.30 |
| CHEMBL1782139 | — | — | 1 | 7.57 |
| CHEMBL1782137 | — | — | 1 | 7.50 |
| CHEMBL1782138 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782141 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1782139 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1782137 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL1782138 | — | Ki | = | 387.0 | nM | 6.41 |