Assay Detail

CHEMBL1785508

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Functional

Induction of apoptosis in human U937 cells

ChEMBL ↗

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Target

U-937 (CHEMBL612794) ↗

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Primary target U-937

CHEMBL612794

Anchored from Assay target.

Protein identity U-937

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	U-937
Confidence	1 — Organism
Curated By	Autocuration

Target

U-937 (CHEMBL612794) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.

Van Cleemput M, Cattoor K, De Bosscher K, Haegeman G, De Keukeleire D, Heyerick A.
J Nat Prod (2009) 72 : 1220 -1230
PubMed 19476340 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.47	5.47

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL512227	HUMULONE	—	1	5.47

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL512227	HUMULONE	IC50	=	3400.0	nM	5.47