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Assay Detail

CHEMBL1785644

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
Genès C, Lenglet G, Depauw S, Nhili R, Prado S, David-Cordonnier MH, Michel S, Tillequin F, Porée FH.
Eur J Med Chem (2011) 46 : 2117 -2131
PubMed 21435753 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.01 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1784004 1 7.16
CHEMBL1783997 1 7.12
CHEMBL1783542 1 7.11
CHEMBL1784006 1 6.96
CHEMBL1783995 1 6.92
CHEMBL1783996 1 6.64
CHEMBL1783544 1 6.64
CHEMBL1783543 1 6.62
CHEMBL1784001 1 6.01
CHEMBL1783998 1 5.99
CHEMBL1783536 1 5.85
CHEMBL1783539 1 5.78
CHEMBL1784007 1 5.76
CHEMBL1783538 1 5.74
CHEMBL1784008 1 5.74
CHEMBL1783541 1 5.58
CHEMBL8443 NITIDINE CHLORIDE 1 5.56
CHEMBL1783999 1 5.50
CHEMBL1784002 1 5.48
CHEMBL1783540 1 5.30
CHEMBL1784000 1 5.26
CHEMBL1784003 1 5.24
CHEMBL1783537 1 5.21
CHEMBL1784005 1 5.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1784004 IC50 = 70.0 nM 7.16
CHEMBL1783997 IC50 = 75.0 nM 7.12
CHEMBL1783542 IC50 = 78.0 nM 7.11
CHEMBL1784006 IC50 = 110.0 nM 6.96
CHEMBL1783995 IC50 = 120.0 nM 6.92
CHEMBL1783996 IC50 = 230.0 nM 6.64
CHEMBL1783544 IC50 = 230.0 nM 6.64
CHEMBL1783543 IC50 = 240.0 nM 6.62
CHEMBL1784001 IC50 = 970.0 nM 6.01
CHEMBL1783998 IC50 = 1020.0 nM 5.99
CHEMBL1783536 IC50 = 1420.0 nM 5.85
CHEMBL1783539 IC50 = 1660.0 nM 5.78
CHEMBL1784007 IC50 = 1730.0 nM 5.76
CHEMBL1783538 IC50 = 1820.0 nM 5.74
CHEMBL1784008 IC50 = 1830.0 nM 5.74
CHEMBL1783541 IC50 = 2630.0 nM 5.58
CHEMBL8443 NITIDINE CHLORIDE IC50 = 2750.0 nM 5.56
CHEMBL1783999 IC50 = 3140.0 nM 5.50
CHEMBL1784002 IC50 = 3330.0 nM 5.48
CHEMBL1783540 IC50 = 4980.0 nM 5.30
CHEMBL1784000 IC50 = 5470.0 nM 5.26
CHEMBL1784003 IC50 = 5770.0 nM 5.24
CHEMBL1783537 IC50 = 6110.0 nM 5.21
CHEMBL1784005 IC50 = 7620.0 nM 5.12