Assay Detail
Binding
CHEMBL1785907
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Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.04 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574782 | — | — | 1 | 8.05 |
| CHEMBL1084856 | — | — | 1 | 8.02 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.00 |
| CHEMBL1083383 | — | — | 1 | 8.00 |
| CHEMBL1085034 | — | — | 1 | 7.99 |
| CHEMBL1085033 | — | — | 1 | 7.99 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL1084951 | — | — | 1 | 7.54 |
| CHEMBL1082898 | — | — | 1 | 7.47 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.46 |
| CHEMBL1083684 | — | — | 1 | 6.98 |
| CHEMBL1083382 | — | — | 1 | 6.97 |
| CHEMBL1083381 | — | — | 1 | 6.85 |
| CHEMBL73460 | — | — | 1 | 6.84 |
| CHEMBL1084064 | — | — | 1 | 6.72 |
| CHEMBL1085095 | — | — | 1 | 6.66 |
| CHEMBL1084702 | — | — | 1 | 6.63 |
| CHEMBL1085092 | — | — | 1 | 6.62 |
| CHEMBL1085093 | — | — | 1 | 6.59 |
| CHEMBL1084063 | — | — | 1 | 6.49 |
| CHEMBL1085467 | — | — | 1 | 6.47 |
| CHEMBL23285 | — | — | 1 | 5.60 |
| CHEMBL1083756 | — | — | 1 | 5.55 |
| CHEMBL1085094 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574782 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1084856 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1083383 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL1085034 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL1085033 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1084951 | — | Ki | = | 28.6 | nM | 7.54 |
| CHEMBL1082898 | — | Ki | = | 33.8 | nM | 7.47 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1083684 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL1083382 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL1083381 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL73460 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL1084064 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL1085095 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL1084702 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL1085092 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL1085093 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL1084063 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL1085467 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL23285 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL1083756 | — | Ki | = | 2810.0 | nM | 5.55 |
| CHEMBL1085094 | — | Ki | = | 3500.0 | nM | 5.46 |