Assay Detail
Binding
CHEMBL1785909
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Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.88 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1085034 | — | — | 1 | 8.26 |
| CHEMBL1084063 | — | — | 1 | 8.19 |
| CHEMBL1083381 | — | — | 1 | 8.16 |
| CHEMBL1085093 | — | — | 1 | 8.14 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.39 |
| CHEMBL574782 | — | — | 1 | 7.34 |
| CHEMBL1083684 | — | — | 1 | 7.21 |
| CHEMBL1084951 | — | — | 1 | 7.19 |
| CHEMBL1083382 | — | — | 1 | 7.18 |
| CHEMBL1083383 | — | — | 1 | 7.16 |
| CHEMBL1085094 | — | — | 1 | 7.15 |
| CHEMBL1085467 | — | — | 1 | 7.11 |
| CHEMBL1085033 | — | — | 1 | 7.11 |
| CHEMBL73460 | — | — | 1 | 7.09 |
| CHEMBL1084702 | — | — | 1 | 6.21 |
| CHEMBL1083756 | — | — | 1 | 6.19 |
| CHEMBL1085095 | — | — | 1 | 6.19 |
| CHEMBL1085092 | — | — | 1 | 6.18 |
| CHEMBL1084064 | — | — | 1 | 6.17 |
| CHEMBL1082898 | — | — | 1 | 6.17 |
| CHEMBL23285 | — | — | 1 | 6.14 |
| CHEMBL1084856 | — | — | 1 | 6.11 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 5.84 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1085034 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL1084063 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL1083381 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL1085093 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL574782 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL1083684 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL1084951 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1083382 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL1083383 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL1085094 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL1085467 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL1085033 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL73460 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL1084702 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL1083756 | — | Ki | = | 643.0 | nM | 6.19 |
| CHEMBL1085095 | — | Ki | = | 644.0 | nM | 6.19 |
| CHEMBL1085092 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL1084064 | — | Ki | = | 682.0 | nM | 6.17 |
| CHEMBL1082898 | — | Ki | = | 684.0 | nM | 6.17 |
| CHEMBL23285 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL1084856 | — | Ki | = | 771.0 | nM | 6.11 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 5250.0 | nM | 5.28 |