Assay Detail
Binding
CHEMBL1785939
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Inhibition of HIF-1 in human deferoxamine treated HCT-116 cells expressing HRE-bla gene pretreated for 30 mins before deferoxamine challenge measured after 24 hrs by fluorometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Toluidinesulfonamide hypoxia-induced factor 1 inhibitors: alleviating drug-drug interactions through use of PubChem data and comparative molecular field analysis guided synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.26 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1784702 | — | — | 1 | 7.40 |
| CHEMBL1386228 | — | — | 1 | 7.20 |
| CHEMBL1784701 | — | — | 1 | 7.00 |
| CHEMBL1784700 | — | — | 1 | 6.20 |
| CHEMBL1784699 | — | — | 1 | 5.80 |
| CHEMBL1784698 | — | — | 1 | 5.50 |
| CHEMBL1319809 | — | — | 1 | 4.70 |
| CHEMBL1450745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1784702 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1386228 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1784701 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1784700 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL1784699 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL1784698 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL1319809 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL1450745 | — | IC50 | > | 10000.0 | nM | - |