Assay Detail
Binding
CHEMBL1785972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ditolylguanidine from sigma 2 receptor PCP binding site in rat liver membrane
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.08 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.19 |
| CHEMBL1783450 | — | — | 1 | 7.04 |
| CHEMBL1783465 | — | — | 1 | 6.27 |
| CHEMBL1783460 | — | — | 1 | 6.24 |
| CHEMBL1783458 | — | — | 1 | 6.04 |
| CHEMBL1783449 | — | — | 1 | 5.74 |
| CHEMBL1783454 | — | — | 1 | 5.56 |
| CHEMBL1783463 | — | — | 1 | 5.41 |
| CHEMBL1783461 | — | — | 1 | 5.20 |
| CHEMBL1783448 | — | — | 1 | - |
| CHEMBL1783451 | — | — | 1 | - |
| CHEMBL1783452 | — | — | 1 | - |
| CHEMBL1783453 | — | — | 1 | - |
| CHEMBL1783455 | — | — | 1 | - |
| CHEMBL1783456 | — | — | 1 | - |
| CHEMBL1783457 | — | — | 1 | - |
| CHEMBL1783459 | — | — | 1 | - |
| CHEMBL1783462 | — | — | 1 | - |
| CHEMBL1783426 | — | — | 1 | - |
| CHEMBL1783464 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL1783450 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL1783465 | — | Ki | = | 542.0 | nM | 6.27 |
| CHEMBL1783460 | — | Ki | = | 581.0 | nM | 6.24 |
| CHEMBL1783458 | — | Ki | = | 903.0 | nM | 6.04 |
| CHEMBL1783449 | — | Ki | = | 1830.0 | nM | 5.74 |
| CHEMBL1783454 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL1783463 | — | Ki | = | 3890.0 | nM | 5.41 |
| CHEMBL1783461 | — | Ki | = | 6320.0 | nM | 5.20 |
| CHEMBL1783448 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783451 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783452 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783453 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783455 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783456 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783457 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783459 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783462 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783426 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783464 | — | Ki | > | 10000.0 | nM | - |