Assay Detail
Binding
CHEMBL1785974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)-MK801 from NMDA receptor PCP binding site in pig cortex membrane after 90 mins by liquid scintillation counting
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.52 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1165411 | DEXOXADROL | 2.0 | 1 | 7.72 |
| CHEMBL305904 | ETOXADROL | 2.0 | 1 | 7.66 |
| CHEMBL1783455 | — | — | 1 | 7.62 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 7.55 |
| CHEMBL1783467 | — | — | 1 | 7.16 |
| CHEMBL1783456 | — | — | 1 | 6.81 |
| CHEMBL1783469 | — | — | 1 | 6.59 |
| CHEMBL1783457 | — | — | 1 | 6.15 |
| CHEMBL1783468 | — | — | 1 | 6.14 |
| CHEMBL1783451 | — | — | 1 | 5.63 |
| CHEMBL1783466 | — | — | 1 | 5.49 |
| CHEMBL1783452 | — | — | 1 | 5.16 |
| CHEMBL1783465 | — | — | 1 | 5.12 |
| CHEMBL1783448 | — | — | 1 | - |
| CHEMBL1783449 | — | — | 1 | - |
| CHEMBL1783450 | — | — | 1 | - |
| CHEMBL1783453 | — | — | 1 | - |
| CHEMBL1783454 | — | — | 1 | - |
| CHEMBL1783458 | — | — | 1 | - |
| CHEMBL1783459 | — | — | 1 | - |
| CHEMBL1783460 | — | — | 1 | - |
| CHEMBL1783461 | — | — | 1 | - |
| CHEMBL1783426 | — | — | 1 | - |
| CHEMBL1783464 | — | — | 1 | - |
| CHEMBL1783463 | — | — | 1 | - |
| CHEMBL1783462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1165411 | DEXOXADROL | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL305904 | ETOXADROL | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1783455 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL275528 | PHENCYCLIDINE | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1783467 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL1783456 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL1783469 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL1783457 | — | Ki | = | 713.0 | nM | 6.15 |
| CHEMBL1783468 | — | Ki | = | 717.0 | nM | 6.14 |
| CHEMBL1783451 | — | Ki | = | 2350.0 | nM | 5.63 |
| CHEMBL1783466 | — | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL1783452 | — | Ki | = | 6870.0 | nM | 5.16 |
| CHEMBL1783465 | — | Ki | = | 7670.0 | nM | 5.12 |
| CHEMBL1783448 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783449 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783450 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783453 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783454 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783458 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783459 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783460 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783461 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783426 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783464 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783463 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783462 | — | Ki | > | 10000.0 | nM | - |