Assay Detail
Functional
CHEMBL1785978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative allosteric modulator activity at rat calcium sensing receptor expressed in HEK cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Extracellular calcium-sensing receptor (CHEMBL2516) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The discovery of novel calcium sensing receptor negative allosteric modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.50 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1198855 | RONACALERET | 2.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1198855 | RONACALERET | IC50 | = | 320.0 | nM | 6.50 |