Assay Detail
Binding
CHEMBL1786327
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Inhibition of human recombinant eNOS by microtiter plate assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.68 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783094 | — | — | 1 | 6.60 |
| CHEMBL1783095 | — | — | 1 | 5.62 |
| CHEMBL1783097 | — | — | 1 | 4.82 |
| CHEMBL114551 | GW-274150 | 2.0 | 1 | - |
| CHEMBL1783098 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783094 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1783095 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1783097 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL114551 | GW-274150 | IC50 | = | 466000.0 | nM | - |
| CHEMBL1783098 | — | IC50 | > | 100000.0 | nM | - |