Assay Detail
Functional
CHEMBL1786465
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Antagonist activity at alpha2bbeta3 integrin receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 9.33 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782661 | — | — | 1 | 10.64 |
| CHEMBL1782660 | — | — | 1 | 9.74 |
| CHEMBL599119 | — | — | 1 | 9.68 |
| CHEMBL1782663 | — | — | 1 | 9.40 |
| CHEMBL1083695 | — | — | 1 | 9.36 |
| CHEMBL599138 | — | — | 1 | 9.25 |
| CHEMBL1782662 | — | — | 1 | 9.11 |
| CHEMBL1782659 | — | — | 1 | 9.03 |
| CHEMBL1782657 | — | — | 1 | 9.01 |
| CHEMBL1782658 | — | — | 1 | 8.92 |
| CHEMBL598737 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782661 | — | IC50 | = | 0.023 | nM | 10.64 |
| CHEMBL1782660 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL599119 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL1782663 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1083695 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL599138 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL1782662 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL1782659 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL1782657 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL1782658 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL598737 | — | IC50 | = | 3.0 | nM | 8.52 |