Assay Detail
Functional
CHEMBL1786466
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Antagonist activity at alphavbeta3 integrin receptor human VSMC assessed as inhibition of vitronectin-induced cell adhesion
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | VSMC |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.99 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782662 | — | — | 1 | 7.80 |
| CHEMBL599138 | — | — | 1 | 7.51 |
| CHEMBL599119 | — | — | 1 | 7.32 |
| CHEMBL1782663 | — | — | 1 | 7.28 |
| CHEMBL1782660 | — | — | 1 | 7.28 |
| CHEMBL1782661 | — | — | 1 | 7.14 |
| CHEMBL1083695 | — | — | 1 | 6.96 |
| CHEMBL598737 | — | — | 1 | 6.72 |
| CHEMBL1782659 | — | — | 1 | 6.41 |
| CHEMBL1782657 | — | — | 1 | 6.28 |
| CHEMBL1782658 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782662 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL599138 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL599119 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1782663 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1782660 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1782661 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1083695 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL598737 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1782659 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1782657 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1782658 | — | IC50 | = | 660.0 | nM | 6.18 |