Assay Detail
Functional
CHEMBL1786468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at AhR in human MCF-7 cells assessed as increase of CYP1A1-dependent 7-ethoxyresorufin O-deethylase activity
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.39 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL600169 | — | — | 1 | 6.70 |
| CHEMBL599550 | — | — | 1 | 6.57 |
| CHEMBL599338 | — | — | 1 | 6.48 |
| CHEMBL599551 | — | — | 1 | 6.35 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | — | 1 | 5.85 |
| CHEMBL599322 | — | — | 1 | - |
| CHEMBL611384 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL600169 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL599550 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL599338 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL599551 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL599322 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL611384 | — | EC50 | > | 10000.0 | nM | - |