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Assay Detail

CHEMBL1786488

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HSP70 by fluorescence polarization assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
Macias AT, Williamson DS, Allen N, Borgognoni J, Clay A, Daniels Z, Dokurno P, Drysdale MJ, Francis GL, Graham CJ, Howes R, Matassova N, Murray JB, Parsons R, Shaw T, Surgenor AE, Terry L, Wang Y, Wood M, Massey AJ.
J Med Chem (2011) 54 : 4034 -4041
PubMed 21526763 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.91 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL14830 ADENOSINE DIPHOSPHATE 0.5 1 6.96
CHEMBL470334 1 6.92
CHEMBL462871 1 6.51
CHEMBL1784884 1 6.35
CHEMBL538168 1 5.98
CHEMBL1784882 1 5.96
CHEMBL515570 1 5.89
CHEMBL473972 1 5.84
CHEMBL1614761 1 5.73
CHEMBL1784883 1 5.39
CHEMBL516357 1 5.37
CHEMBL1614768 1 5.37
CHEMBL516197 1 5.35
CHEMBL451058 1 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL14830 ADENOSINE DIPHOSPHATE Ki = 110.0 nM 6.96
CHEMBL470334 Ki = 120.0 nM 6.92
CHEMBL462871 Ki = 310.0 nM 6.51
CHEMBL1784884 Ki = 450.0 nM 6.35
CHEMBL538168 Ki = 1050.0 nM 5.98
CHEMBL1784882 Ki = 1100.0 nM 5.96
CHEMBL515570 Ki = 1290.0 nM 5.89
CHEMBL473972 Ki = 1440.0 nM 5.84
CHEMBL1614761 Ki = 1850.0 nM 5.73
CHEMBL1784883 Ki = 4070.0 nM 5.39
CHEMBL516357 Ki = 4310.0 nM 5.37
CHEMBL1614768 Ki = 4320.0 nM 5.37
CHEMBL516197 Ki = 4460.0 nM 5.35
CHEMBL451058 Ki = 8300.0 nM 5.08