Assay Detail
Binding
CHEMBL1786572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Hepatitis C virus subtype 1b NS5B activity assessed as inhibition of poly(A)n.oligo(dT)12-18-directed incorporation of [3H]-UTP into DNA after 45 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid hepatitis C virus polymerase NS5B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.99 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1784254 | — | — | 1 | 6.47 |
| CHEMBL1784248 | — | — | 1 | 6.42 |
| CHEMBL1784250 | — | — | 1 | 6.36 |
| CHEMBL1784249 | — | — | 1 | 6.34 |
| CHEMBL211639 | — | — | 1 | 6.19 |
| CHEMBL1784251 | — | — | 1 | 6.19 |
| CHEMBL1784239 | — | — | 1 | 6.10 |
| CHEMBL1784253 | — | — | 1 | 6.09 |
| CHEMBL1784252 | — | — | 1 | 5.99 |
| CHEMBL1784246 | — | — | 1 | 5.79 |
| CHEMBL1784255 | — | — | 1 | 5.64 |
| CHEMBL1784256 | — | — | 1 | 5.57 |
| CHEMBL1784247 | — | — | 1 | 5.39 |
| CHEMBL1784257 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1784254 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1784248 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1784250 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1784249 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL211639 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1784251 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1784239 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1784253 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1784252 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1784246 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL1784255 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL1784256 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1784247 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL1784257 | — | IC50 | = | 5200.0 | nM | 5.28 |