Assay Detail
Functional
CHEMBL1786573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus subtype 1b infected in human Huh7 cells by replicon assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid hepatitis C virus polymerase NS5B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.20 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211639 | — | — | 1 | 6.52 |
| CHEMBL1784254 | — | — | 1 | 6.40 |
| CHEMBL1784251 | — | — | 1 | 6.16 |
| CHEMBL1784249 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211639 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1784254 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1784251 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1784249 | — | EC50 | = | 1900.0 | nM | 5.72 |